Amitriptyline hydrochloride is an antidepressant with sedative effects. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. It is indicated for the relief of symptoms of depression.

Amoxapine is indicated for the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. It is indicated for depression accompanied by anxiety or agitation.

Anafranil (clomipramine hydrochloride), is an antiobsessional drug that belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants. Anafranil is indicated for the treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder (OCD).

Citalopram hydrobromide is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other available antidepressant agents. Citalopram tablets are indicated for the treatment of depression.

Cymbalta® is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for major depressive disorder and generalized anxiety disorder, for the management of neuropathic pain (DPNP) associated with diabetic peripheral neuropathy, and for the management of fibromyalgia.

Doxepin hydrochloride is one of a class of psychotherapeutic agents known as dibenzoxepin tricyclic compounds. Doxepin is recommended for the treatment of psychoneurotic patients with depression and/or anxiety.

Effexor (venlafaxine hydrochloride) is indicated for the treatment of major depressive disorder. The efficacy of Effexor (venlafaxine hydrochloride) as a treatment for major depressive disorder was established in 5 placebo-controlled, short-term trials.